How Does ALA Function as an Antioxidant?

ALA is known to have antioxidant properties which means it is able to neutralize free radicals and unstable atoms that lead to cell damage. Also what makes ALA unique among the group of antioxidants is that it is both water and fat-soluble which in turn allows it to work throughout the body. Also of note is that ALA may help recharge other antioxidants like vitamins C and E and glutathione thus it plays a role in improving the body’s total antioxidant defense system.

Could ALA Support Blood Sugar Management?

Research reports on the role of ALA in glucose metabolism which is that some studies put forth that which ALA supplementation does in fact improve insulin sensitivity and support what we term as healthy blood sugar levels. That said results are mixed and also it is early days for research which will see large-scale conclusions drawn at this time.

What Is the Connection Between ALA and Nerve Health?

ALA has in the past been looked at for what it may do for nerve health which in turn includes people that have peripheral neuropathy. We see that some early studies which ALA was put in to report that it does in fact improve symptoms like pain, burning, and numbness which are related to nerve damage. That said we still need large-scale better designed studies to prove out these results.

Can ALA Influence Cardiovascular Health?

Preliminary research has looked at what ALA does for cardiovascular health. We see that in some studies which report improved endothelial function and lower levels of oxidative stress and inflammation which are players in heart health. But also in this area the research isn’t definitive and we need more study.

Does ALA factor into weight management?

Some research has looked into ALA’s role in weight management. We see that studies report mild weight and BMI reduction in people taking ALA supplements. But what clinical value these results have is still to be determined and we require more in-depth research.

What is the information on dosages and safety of ALA?

ALA supplements present in a range of doses which typically go from 300mg to 600mg per day. We see reports of use up to 1,200 mg daily. ALA is for the most part considered safe for all people when used as directed. That said we do see reports of GI issues, skin rashes, and low blood sugar. People with diabetes and which are taking meds should talk to their health care provider before starting ALA supps.

What is the best way to include ALA in a supplement regimen?

ALA is a supplement which is present in many forms such as capsules, tablets and also in intravenous preparations. Also reports that food intake may play a role in the bioavailability of ALA which is why it is put forth that best results in terms of absorption are achieved when taken on an empty stomach. As is the case with any supplement it is advised by health care professionals that you consult them to determine what dose and which form of ALA is best for your health.

Are There Any Potential Interactions or Contraindications with ALA?

ALA may interact with certain medications, including those for thyroid conditions, chemotherapy agents, and diabetes medications. It may also lower blood sugar levels, which could be problematic for individuals on blood sugar-lowering medications. Additionally, due to limited research, ALA supplementation is not recommended for pregnant or breastfeeding women without medical supervision.

Conclusion: Is ALA For You?

Alpha-lipoic-acid is a natural compound that has anti-oxidant properties which we see put to use in many health applications which include support for nerve health, blood sugar metabolism, and cardiovascular function. While research is still out and not all studies report the same results, ALA supplements are generally considered safe for the great majority of people. As is the case with any supplement it is very important to check with your health care provider first to see what is best for your specific health concerns also to report on possible drug interactions or health condition issues.

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References

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• Jacob, S., Henriksen, E. J., et al. (1999). Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittel-Forschung, 49(8), 872–874.
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• Kunt, T., Forst, T., et al. (1999). Alpha-lipoic acid reduces expression of adhesion molecules in human endothelial cells. Metabolism, 48(4), 504–506.
• Koh, E. H., Lee, W. J., et al. (2011). Effects of alpha-lipoic acid on body weight in obese subjects. The American Journal of Medicine, 124(1), 85.e1–85.e8.
• Moini, H., Packer, L., & Saris, N. E. (2002). Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicology and Applied Pharmacology, 182(1), 84–90.
• Ziegler, D., Nowak, H., et al. (2004). Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabetic Medicine, 21(2), 114–121.
• Gorąca, A., et al. (2011). Lipoic acid–biological activity and therapeutic potential. Pharmacological Reports, 63(4), 849–858.
• Packer, L., Kraemer, K., & Rimbach, G. (2001). Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition, 17(10), 888–895.

Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before starting any new supplement or health regimen. The information presented here is based on credible sources but does not replace individualized advice from a healthcare provider.

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